RESULT of inhibition varied ranging from (7.7+0.6 mm) to

RESULT

Antibacterial
activity of Croton macrostachyus stem
bark extract

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The
antibacterial effects of C. macrostachyus stem bark extracts showed
effective antibacterial activity against all the tested bacterial strains. The
diameter of the zone of inhibition varied ranging from (7.7+0.6 mm) to (17+1.0
mm) diameter (Table 1). All the water, chloroform and methanolic extracts of C.
macrostachyus stem bark caused 7.7+0.6 mm to 17+1 mm inhibition zones of bacterial growth. The bacteria, which
were inhibited with a zone diameter of 17+1 mm, were S. aureus (standard) (with methanol extracts)
and the lowest inhibition zone (7.7+0.6
mm) was found against E. coli (clinical)
which is extracted by methanol. The antibiotic Chloramphenicol (positive
controls) was frequently high. DMSO, which was
the negative control had no inhibitory activity.

 

Table 1.
Antibacterial activity of the chloroform, methanol and water extracts of Croton. macrostachyus stem bark against clinical
and standard strains of S. aureus and
E. coli.

 
Antibacterial

 
Extraction
Solvent

Diameter
of inhibition (mm)

E.
coli

S.
aureus

clinical

standard

clinical

standard

C. macrostachyus

Chloroform

12+1.0a

13.0 +1.0ab

11.0+1.1a

16.0+3.6b

 

Methanol

12+1.0a

15.0+1.5b

12.7+1.0a

17+1.0b

 

Water

7.7+ 0.6a

10+1.0a

8.67+0.6a

10+1.0a

Chloramphenicol

 

39+1.0

42+1.0

42+1.0

39+1.0

Values are means of triplicate determinations;
Values within the same column followed by different superscripts are
significantly different at (P